Heads Up Sit n Go requires a very unique style of play compared to normal Sit N Goes or multi-table tournaments (MTT Strategy). Because of this, good players tend to make more from Sit n Goes because there are so many weaker players who don’t know how to play the games well. To make money in these Sit n Goes, you only realistically need to win 6 out of 10 matches – meaning you can easily afford to get unlucky losing all ins. As long as you make the right profitable calls, and are ahead the majority of the time during all-ins, you should make money from these.
Starting Hands Preflop
Unlike short-handed Sngs and tournaments where you have to wait for premium hands or pocket pairs; heads up play requires you to open up and play a massive range of hands. Quite frankly every hand is playable in heads up Sngs under the right conditions. The fact your opponent will only hit the flop with a pair 40% of the time; even playing 72 aggressively will give you value in the long run.
Raising Hands in Dealer Position Preflop
When you’re in the dealer position (SB), you should raise as often with possible regardless of your hand. This is because you have position on the flop, turn and river; so any continuation bet is likely to make your opponent fold most times. You should make a pot-sized continuation bet every time you raise preflop regardless of whether you manage to hit anything. For example, J9 suited preflop isn’t a terrible hand heads up, so you should raise it in dealer position. When the flop comes A7J, raising here will require your opponent to have an Ace in order to call – he’ll also assume you have a better Ace considering your preflop strength.
Dominate the Game and Don’t Be Predictable
Perhaps the best advice to succeed in heads up Sit n Goes is to be as aggressive as possible. Because your opponent will miss the flop 60% of the time, playing aggressively will earn you value. However the problem here is that even a half-witted opponent will pick up on your bluffs, and re-raise you at any moment to steal the pot. The trick to preventing this from happening is to mix up your hands, and play as unpredictably as possible. If you’re seen as too loose or too tight you’ll be bluffed off pots quite easily. The trick is to balance your play, and trap your opponent when you have a monster hand. Accumulate chips gradually, and wait for that monster hand to trap your opponent all in.

Dominate the Game and Don’t Be Predictable
Wow, this is the most important skillness, several persons can reach it.
Poker, just hobby.